Anti-PASK antibody (1100-1180 aa) (STJ190115)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 1100-1180
General Information
| Short Description | Rabbit polyclonal anti-PAS domain-containing serine/threonine-protein kinase (1100-1180 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PASK |
| Gene ID | 23178 |
| Uniprot ID | PASK_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 1100-1180 |
| Immunogen Region | 1100-1180 aa |
| Specificity | PASK Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids. |
| Function | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells.however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. |
| Protein Name | Pas Domain-Containing Serine/Threonine-Protein KinasePas-KinasePaskinHpask |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Nucleus Of Testis Germ Cells And In The Midpiece Of Sperm Tails |
| Alternative Antibody Names | Anti-Pas Domain-Containing Serine/Threonine-Protein Kinase antibodyAnti-Pas-Kinase antibodyAnti-Paskin antibodyAnti-Hpask antibodyAnti-PASK antibodyAnti-KIAA0135 antibody |
Information sourced from Uniprot.org