| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAS domain-containing serine/threonine-protein kinase (1100-1180 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PASK |
| Gene ID: |
23178 |
| Uniprot ID: |
PASK_HUMAN |
| Immunogen Region: |
1100-1180 aa |
| Specificity: |
PASK Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 1100-1180 |
| Post Translational Modifications | Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids. |
| Function | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells.however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. |
| Protein Name | Pas Domain-Containing Serine/Threonine-Protein KinasePas-KinasePaskinHpask |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Nucleus Of Testis Germ Cells And In The Midpiece Of Sperm Tails |
| Alternative Antibody Names | Anti-Pas Domain-Containing Serine/Threonine-Protein Kinase antibodyAnti-Pas-Kinase antibodyAnti-Paskin antibodyAnti-Hpask antibodyAnti-PASK antibodyAnti-KIAA0135 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
