Anti-PARVB antibody (1-100) (STJ115127)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PARVB (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARVB |
| Gene ID | 29780 |
| Uniprot ID | PARVB_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MSSAPRSPTPRPRRMKKDES FLGKLGGTLARKRRAREVSD LQEEGKNAINSPMSPALVDV HPEDTQLEENEERTMIDPTS KEDPKFKELVKVLLDWINDV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human PARVB (NP_037459.2). |
Additional Info
| Tissue Specificity | Expressed predominantly in heart and skeletal muscle. |
| Function | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. |
| Protein Name | Beta-ParvinAffixin |
| Database Links | Reactome: R-HSA-446353Reactome: R-HSA-446388 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell ProjectionLamellipodiumMyofibrilSarcomereZ LineConstituent Of Focal AdhesionsDetected At The Tips Of The Leading Edge Of CellsColocalizes With F-Actin At The Tips Of Lamellipodia |
| Alternative Antibody Names | Anti-Beta-Parvin antibodyAnti-Affixin antibodyAnti-PARVB antibodyAnti-CGI-56 antibody |
Information sourced from Uniprot.org