Anti-PARVA antibody (1-100) (STJ11105342)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Alpha-Parvin (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARVA |
| Gene ID | 55742 |
| Uniprot ID | PARVA_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MATSPQKSPSVPKSPTPKSP PSRKKDDSFLGKLGGTLARR KKAKEVSELQEEGMNAINLP LSPIPFELDPEDTMLEENEV RTMVDPNSRSDPKLQELMKV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PARVA (NP_060692.3). |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. |
| Function | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. |
| Protein Name | Alpha-ParvinActopaxinCh-IlkbpCalponin-Like Integrin-Linked Kinase-Binding ProteinMatrix-Remodeling-Associated Protein 2 |
| Database Links | Reactome: R-HSA-446343Reactome: R-HSA-446353Reactome: R-HSA-446388 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Alpha-Parvin antibodyAnti-Actopaxin antibodyAnti-Ch-Ilkbp antibodyAnti-Calponin-Like Integrin-Linked Kinase-Binding Protein antibodyAnti-Matrix-Remodeling-Associated Protein 2 antibodyAnti-PARVA antibodyAnti-MXRA2 antibody |
Information sourced from Uniprot.org