Anti-PARP16 antibody (STJ192042)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Protein mono-ADP-ribosyltransferase PARP16 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARP16 |
| Gene ID | 54956 |
| Uniprot ID | PAR16_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PAR16 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp16Adp-Ribosyltransferase Diphtheria Toxin-Like 15Poly Adp-Ribose Polymerase 16Parp-16 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-9683610Reactome: R-HSA-9694631 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane Protein |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp16 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 15 antibodyAnti-Poly Adp-Ribose Polymerase 16 antibodyAnti-Parp-16 antibodyAnti-PARP16 antibodyAnti-ARTD15 antibodyAnti-C15orf30 antibody |
Information sourced from Uniprot.org