Anti-PARP12 antibody (STJ192237)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Protein mono-ADP-ribosyltransferase PARP12 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARP12 |
| Gene ID | 64761 |
| Uniprot ID | PAR12_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PAR12 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication. Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4. Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1. Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp12Adp-Ribosyltransferase Diphtheria Toxin-Like 12Artd12Poly Adp-Ribose Polymerase 12Parp-12Zinc Finger Ccch Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusGolgi ApparatusTrans-Golgi NetworkCytoplasmStress GranuleTranslocates From The Golgi Complex To Stress Granules Upon Stress Conditions |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp12 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 12 antibodyAnti-Artd12 antibodyAnti-Poly Adp-Ribose Polymerase 12 antibodyAnti-Parp-12 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 1 antibodyAnti-PARP12 antibodyAnti-ZC3HDC1 antibody |
Information sourced from Uniprot.org