| Function | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. Inhibits the type I interferon activated signaling pathway. Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity. Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp11Adp-Ribosyltransferase Diphtheria Toxin-Like 11Artd11Poly Adp-Ribose Polymerase 11Parp-11 |
| Database Links | |
| Cellular Localisation | NucleusNuclear Pore ComplexColocalizes With Nup153 At Nuclear Pores |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp11 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 11 antibodyAnti-Artd11 antibodyAnti-Poly Adp-Ribose Polymerase 11 antibodyAnti-Parp-11 antibodyAnti-PARP11 antibodyAnti-C12orf6 antibody |
Information sourced from Uniprot.org
