| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PANX1 (50-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PANX1 |
| Gene ID: |
24145 |
| Uniprot ID: |
PANX1_HUMAN |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Pannexin 1 (NP_056183.2). |
| Immunogen Sequence: |
ISLAFAQEISIGTQISCFSP SSFSWRQAAFVDSYCWAAVQ QKNSLQSESGNLPLWLHKFF PYILLLFAILLYLPPLFWRF AAAPHICSDLKFIMEELDKV Y |
| Tissue Specificity | Widely expressed. Highest expression is observed in oocytes and brain. Detected at very low levels in sperm cells. |
| Post Translational Modifications | S-nitrosylation inhibits channel currents and ATP release. N-glycosylation may play a role in cell surface targeting. Exists in three glycosylation states: non-glycosylated (GLY0), high-mannose glycosylated (GLY1), and fully mature glycosylated (GLY2). |
| Function | Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Plays a critical role in oogenesis. |
| Protein Name | Pannexin-1 |
| Database Links | Reactome: R-HSA-112303Reactome: R-HSA-844456 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionGap JunctionEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Pannexin-1 antibodyAnti-PANX1 antibodyAnti-MRS1 antibodyAnti-UNQ2529 antibodyAnti-PRO6028 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
