Anti-PANK2 antibody (STJ192933)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Pantothenate kinase 2, mitochondrial for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PANK2 |
| Gene ID | 80025 |
| Uniprot ID | PANK2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PANK2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Synthesized as a 62-kDa precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 59-kDa intermediate to yield the mature mitochondrial 48-kDa subunit. |
| Function | Isoform 1: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC). Isoform 4: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. |
| Protein Name | Pantothenate Kinase 2 - MitochondrialHpank2Pantothenic Acid Kinase 2 Cleaved Into - Pantothenate Kinase 2 - Mitochondrial Intermediate FormIpank2 - Pantothenate Kinase 2 - Mitochondrial Mature FormMpank2 |
| Database Links | Reactome: R-HSA-196783 |
| Cellular Localisation | Isoform 1: MitochondrionMitochondrion Intermembrane SpaceNucleusLocalizes Predominantly To The Mitochondria And To A Lesser Extent To The NucleusFound In Both The Mitochondria And The Nucleus Throughout The Cell CycleWith The Exception Of The G2/M Phase When It Is Restricted To MitochdondriaIsoform 2: CytoplasmIsoform 3: CytoplasmIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-Pantothenate Kinase 2 - Mitochondrial antibodyAnti-Hpank2 antibodyAnti-Pantothenic Acid Kinase 2 Cleaved Into - Pantothenate Kinase 2 - Mitochondrial Intermediate Form antibodyAnti-Ipank2 - Pantothenate Kinase 2 - Mitochondrial Mature Form antibodyAnti-Mpank2 antibodyAnti-PANK2 antibodyAnti-C20orf48 antibody |
Information sourced from Uniprot.org