Anti-PALLD antibody (450-530 aa) (STJ94950)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from Palladin at the amino acid range 450-530
General Information
| Short Description | Rabbit polyclonal anti-Palladin (450-530 aa) for use in IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PALLD |
| Gene ID | 23022 |
| Uniprot ID | PALLD_HUMAN |
| Immunogen | Synthesized peptide derived from Palladin at the amino acid range 450-530 |
| Immunogen Region | 450-530 aa |
| Specificity | Palladin Polyclonal Antibody detects endogenous levels of Palladin protein. |
Additional Info
| Post Translational Modifications | Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines. Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility. |
| Function | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. |
| Protein Name | PalladinSih002Sarcoma Antigen Ny-Sar-77 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionMyofibrilSarcomereZ LineCell ProjectionRufflePodosomeLamellipodiumAxonGrowth ConeLocalizes To Stress Fibers And Z LinesPreferentially Expressed In The Excitatory Presynaptic Terminals |
| Alternative Antibody Names | Anti-Palladin antibodyAnti-Sih002 antibodyAnti-Sarcoma Antigen Ny-Sar-77 antibodyAnti-PALLD antibodyAnti-KIAA0992 antibodyAnti-CGI-151 antibody |
Information sourced from Uniprot.org