| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAIP1 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAIP1 |
| Gene ID: |
10605 |
| Uniprot ID: |
PAIP1_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PAIP1 (NP_877590.1). |
| Immunogen Sequence: |
MSDGFDRAPEQTRPLRAPPS SQDKIPQQNSESAMAKPQVV VAPVLMSKLSVNAPEFYPSG YSSSYTESYEDGCEDYPTLS EYVQDFLNHLTEQPGSFETE IEQFAETLNGCVTTDDALQE LVELIYQQATSIPNFSYMGA RLCNYLSHHLTISPQSGNFR QLLLQRCRTEYEVKDQAAKG DEVTRKRFHAFVLFLGELYL NLEIKGTNGQVTRADILQVG LRELLNALFSNPMDDNLIC |
| Function | Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis. |
| Protein Name | Polyadenylate-Binding Protein-Interacting Protein 1Pabp-Interacting Protein 1Paip-1Poly(A-Binding Protein-Interacting Protein 1 |
| Database Links | Reactome: R-HSA-429947 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Polyadenylate-Binding Protein-Interacting Protein 1 antibodyAnti-Pabp-Interacting Protein 1 antibodyAnti-Paip-1 antibodyAnti-Poly(A-Binding Protein-Interacting Protein 1 antibodyAnti-PAIP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
