| Function | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG.the mechanism of inhibition appears to be gene-dependent. |
| Protein Name | Paxip1-Associated Glutamate-Rich Protein 1Glutamate-Rich Coactivator Interacting With Src1GasPaxip1-Associated Protein 1Ptip-Associated Protein 1 |
| Database Links | Reactome: R-HSA-5617472Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paxip1-Associated Glutamate-Rich Protein 1 antibodyAnti-Glutamate-Rich Coactivator Interacting With Src1 antibodyAnti-Gas antibodyAnti-Paxip1-Associated Protein 1 antibodyAnti-Ptip-Associated Protein 1 antibodyAnti-PAGR1 antibodyAnti-C16orf53 antibodyAnti-PA1 antibody |
Information sourced from Uniprot.org
