Anti-PAGR1 antibody (163-213 aa) (STJ194476)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PA1 at the amino acid range 163-213
General Information
| Short Description | Rabbit polyclonal anti-PAXIP1-associated glutamate-rich protein 1 (163-213 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAGR1 |
| Gene ID | 79447 |
| Uniprot ID | PAGR1_HUMAN |
| Immunogen | Synthesized peptide derived from the human PA1 at the amino acid range 163-213 |
| Immunogen Region | 163-213 aa |
| Specificity | This antibody detects endogenous levels of PA1 at Human |
Additional Info
| Function | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG.the mechanism of inhibition appears to be gene-dependent. |
| Protein Name | Paxip1-Associated Glutamate-Rich Protein 1Glutamate-Rich Coactivator Interacting With Src1GasPaxip1-Associated Protein 1Ptip-Associated Protein 1 |
| Database Links | Reactome: R-HSA-5617472Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paxip1-Associated Glutamate-Rich Protein 1 antibodyAnti-Glutamate-Rich Coactivator Interacting With Src1 antibodyAnti-Gas antibodyAnti-Paxip1-Associated Protein 1 antibodyAnti-Ptip-Associated Protein 1 antibodyAnti-PAGR1 antibodyAnti-C16orf53 antibodyAnti-PA1 antibody |
Information sourced from Uniprot.org