| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAXIP1-associated glutamate-rich protein 1 (163-213 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAGR1 |
| Gene ID: |
79447 |
| Uniprot ID: |
PAGR1_HUMAN |
| Immunogen Region: |
163-213 aa |
| Specificity: |
This antibody detects endogenous levels of PA1 at Human |
| Immunogen: |
Synthesized peptide derived from the human PA1 at the amino acid range 163-213 |
| Function | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG.the mechanism of inhibition appears to be gene-dependent. |
| Protein Name | Paxip1-Associated Glutamate-Rich Protein 1Glutamate-Rich Coactivator Interacting With Src1GasPaxip1-Associated Protein 1Ptip-Associated Protein 1 |
| Database Links | Reactome: R-HSA-5617472Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paxip1-Associated Glutamate-Rich Protein 1 antibodyAnti-Glutamate-Rich Coactivator Interacting With Src1 antibodyAnti-Gas antibodyAnti-Paxip1-Associated Protein 1 antibodyAnti-Ptip-Associated Protein 1 antibodyAnti-PAGR1 antibodyAnti-C16orf53 antibodyAnti-PA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
