Anti-PAFAH1B3 antibody (STJA0008126)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PAFAH1B3
General Information
| Short Description | Rabbit polyclonal anti-Platelet-activating factor acetylhydrolase IB subunit alpha1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAFAH1B3 |
| Gene ID | 5050 |
| Uniprot ID | PA1B3_HUMAN |
| Immunogen | Synthesized peptide derived from human PAFAH1B3 |
| Specificity | This antibody detects endogenous levels of PAFAH1B3 at Human, Mouse, Rat |
Additional Info
| Function | Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha1Paf Acetylhydrolase 29 Kda SubunitPaf-Ah 29 Kda SubunitPaf-Ah Subunit GammaPafah Subunit Gamma |
| Database Links | Reactome: R-HSA-6811436 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha1 antibodyAnti-Paf Acetylhydrolase 29 Kda Subunit antibodyAnti-Paf-Ah 29 Kda Subunit antibodyAnti-Paf-Ah Subunit Gamma antibodyAnti-Pafah Subunit Gamma antibodyAnti-PAFAH1B3 antibodyAnti-PAFAHG antibody |
Information sourced from Uniprot.org