| Function | Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha2Paf Acetylhydrolase 30 Kda SubunitPaf-Ah 30 Kda SubunitPaf-Ah Subunit BetaPafah Subunit Beta |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha2 antibodyAnti-Paf Acetylhydrolase 30 Kda Subunit antibodyAnti-Paf-Ah 30 Kda Subunit antibodyAnti-Paf-Ah Subunit Beta antibodyAnti-Pafah Subunit Beta antibodyAnti-PAFAH1B2 antibodyAnti-PAFAHB antibody |
Information sourced from Uniprot.org
