Anti-PACSIN3 antibody [PT0794R] (STJA0039355)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3 for use in WB, IHC, IF, ICC, FC and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ICC/FC/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0794R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | WB 1:1000-5000IHC 1:100-300ICC/IF 1:100-300FC 1:100-300IP 1:50-100 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PACSIN3 |
| Gene ID | 29763 |
| Uniprot ID | PACN3_HUMAN |
| Specificity | Endogenous |
Additional Info
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). |
| Function | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3Sh3 Domain-Containing Protein 6511 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideDetected At The Inner Aspect Of The Plasma Membrane In Myotubes |
| Alternative Antibody Names | Anti-Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3 antibodyAnti-Sh3 Domain-Containing Protein 6511 antibodyAnti-PACSIN3 antibody |
Information sourced from Uniprot.org