Anti-PACSIN1 antibody (STJA0008310)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PACSIN1
General Information
| Short Description | Rabbit polyclonal anti-Protein kinase C and casein kinase substrate in neurons protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PACSIN1 |
| Gene ID | 29993 |
| Uniprot ID | PACN1_HUMAN |
| Immunogen | Synthesized peptide derived from human PACSIN1 |
| Specificity | This antibody detects endogenous levels of PACSIN1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). |
| Function | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT.this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis.this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. Binds to membranes via its F-BAR domain and mediates membrane tubulation. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 1Syndapin-1 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCell ProjectionSynapseSynaptosomeRuffle MembraneMembranePeripheral Membrane ProteinCytoplasmic Vesicle MembraneCytosolCell MembraneCytoplasmic SideColocalizes With Mapt In AxonsIn Primary Neuronal CulturesPresent At A High Level In Presynaptic Nerve Terminals And In The Cell BodyColocalizes With Dnm1 At Vesicular Structures In The Cell Body And NeuritesAssociates With Membranes Via Its F-Bar Domain |
| Alternative Antibody Names | Anti-Protein Kinase C And Casein Kinase Substrate In Neurons Protein 1 antibodyAnti-Syndapin-1 antibodyAnti-PACSIN1 antibodyAnti-KIAA1379 antibody |
Information sourced from Uniprot.org