Anti-P63 antibody [TP63/11] (STJ16101861)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenRecombinant human p63 protein
General Information
| Short Description | Mouse monoclonal anti-P63 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | TP63/11 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Purification | Concentrate |
| Dilution Range | IHC-P 1:400-1:800 |
| Formulation | Bioreactor Concentrate with 0.05% Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | CKAP4 |
| Gene ID | 10970 |
| Uniprot ID | CKAP4_HUMAN |
| Immunogen | Recombinant human p63 protein |
Additional Info
| Post Translational Modifications | Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling. Increased phosphorylation during mitosis prevents binding to microtubules. |
| Function | Mediates the anchoring of the endoplasmic reticulum to microtubules. High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. |
| Protein Name | Cytoskeleton-Associated Protein 463-Kda Cytoskeleton-Linking Membrane ProteinClimp-63P63 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-5683826Reactome: R-HSA-6798695Reactome: R-HSA-8957275Reactome: R-HSA-9696264Reactome: R-HSA-9696270 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinCell MembraneCytoplasmCytoskeletonPerinuclear RegionTranslocates To The Perinuclear Region Upon Apf-Stimulation |
| Alternative Antibody Names | Anti-Cytoskeleton-Associated Protein 4 antibodyAnti-63-Kda Cytoskeleton-Linking Membrane Protein antibodyAnti-Climp-63 antibodyAnti-P63 antibodyAnti-CKAP4 antibody |
Information sourced from Uniprot.org