Anti-p53 DINP1 antibody [R06-3R7] (STJA0036882)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human p53 DINP1
General Information
| Short Description | Rabbit monoclonal anti-p53 DINP1 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-3R7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TP53INP1 |
| Gene ID | 94241 |
| Uniprot ID | T53I1_HUMAN |
| Immunogen | A synthesized peptide derived from human p53 DINP1 |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. |
| Protein Name | Tumor Protein P53-Inducible Nuclear Protein 1Stress-Induced ProteinP53-Dependent Damage-Inducible Nuclear Protein 1P53dinp1 |
| Database Links | Reactome: R-HSA-6803204Reactome: R-HSA-6804756 |
| Cellular Localisation | CytoplasmCytosolNucleusPml BodyCytoplasmic VesicleAutophagosomeShuttles Between The Nucleus And The CytoplasmDepending On Cellular Stress ConditionsAnd Re-Localizes To Autophagosomes On Autophagy Activation |
| Alternative Antibody Names | Anti-Tumor Protein P53-Inducible Nuclear Protein 1 antibodyAnti-Stress-Induced Protein antibodyAnti-P53-Dependent Damage-Inducible Nuclear Protein 1 antibodyAnti-P53dinp1 antibodyAnti-TP53INP1 antibodyAnti-P53DINP1 antibodyAnti-SIP antibody |
Information sourced from Uniprot.org