Anti-P3H3 antibody (STJA0007123)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human P3H3
General Information
| Short Description | Rabbit polyclonal anti-Prolyl 3-hydroxylase 3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | P3H3 |
| Gene ID | 10536 |
| Uniprot ID | P3H3_HUMAN |
| Immunogen | Synthesized peptide derived from human P3H3 |
| Specificity | This antibody detects endogenous levels of P3H3 at Human, Mouse |
Additional Info
| Function | Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. |
| Protein Name | Prolyl 3-Hydroxylase 3Leprecan-Like Protein 2Protein B |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Prolyl 3-Hydroxylase 3 antibodyAnti-Leprecan-Like Protein 2 antibodyAnti-Protein B antibodyAnti-P3H3 antibodyAnti-LEPREL2 antibody |
Information sourced from Uniprot.org