Anti-P2RY12 antibody (303-313) (STJ117783)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal P2RY12 (303-313) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | P2RY12 |
| Gene ID | 64805 |
| Uniprot ID | P2Y12_HUMAN |
| Immunogen Region | 303-313 |
| Immunogen Sequence | AVFFICFVPFHFARIPYTLS QTRDVFDCTAENTLFYVKES TLWLTSLNACLDPFIYFFLC KSFRNSLISMLKCPNSATSL SQDNRKKEQDGGDPNEETPM |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 243-342 of human P2RY12 (NP_795345.1). |
Additional Info
| Tissue Specificity | Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. |
| Function | Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. |
| Protein Name | P2y Purinoceptor 12P2y12Adp-Glucose ReceptorAdpg-RP2t(AcP2y(AcP2y(CycP2y12 Platelet Adp ReceptorP2y(AdpSp1999 |
| Database Links | Reactome: R-HSA-392170Reactome: R-HSA-417957Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-P2y Purinoceptor 12 antibodyAnti-P2y12 antibodyAnti-Adp-Glucose Receptor antibodyAnti-Adpg-R antibodyAnti-P2t(Ac antibodyAnti-P2y(Ac antibodyAnti-P2y(Cyc antibodyAnti-P2y12 Platelet Adp Receptor antibodyAnti-P2y(Adp antibodyAnti-Sp1999 antibodyAnti-P2RY12 antibodyAnti-HORK3 antibody |
Information sourced from Uniprot.org