| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-P2X purinoceptor 1 (150-230 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | P2RX1 |
| Gene ID: | 5023 |
| Uniprot ID: | P2RX1_HUMAN |
| Immunogen Region: | 150-230 aa |
| Specificity: | P2RX1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 150-230 |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability. Furthermore, CTP functions as a weak affinity agonist for P2RX1. Plays a role a role in urogenital, immune and cardiovascular function. Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function. In addition, contributes to smooth muscle contractions of the urinary bladder. On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis. On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells. |
| Protein Name | P2x Purinoceptor 1 P2x1 Atp Receptor Purinergic Receptor |
| Database Links | Reactome: R-HSA-139853 Reactome: R-HSA-418346 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Detected At Plasma Membrane Lipid Rafts |
| Alternative Antibody Names | Anti-P2x Purinoceptor 1 antibody Anti-P2x1 antibody Anti-Atp Receptor antibody Anti-Purinergic Receptor antibody Anti-P2RX1 antibody Anti-P2X1 antibody |
Information sourced from Uniprot.org