| Short Description : | Goat polyclonal antibody anti-p15INK4b-Isoform 2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications: | Pep-ELISA/WB |
| Host: | Goat |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 12+14kDa bands observed in Human Gastrointestinal cancer lysates (calculated MW of 8.1kDa according to NP_511042.1). The observed 14kDa cannot represent isoform 1 and therefore |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CDKN2B |
| Gene ID: | 1030 |
| Uniprot ID: | CDN2B_HUMAN |
| Accession Number: | NP_004927.2; NP_511042.1 |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | RQGARERGARP |
| Specificity: | This antibody is expected to recognize isoform 2 (NP_511042.1) only. |
| Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. |
| Protein Name | Cyclin-Dependent Kinase 4 Inhibitor BMultiple Tumor Suppressor 2Mts-2P14-Ink4bP15-Ink4bP15ink4b |
| Database Links | Reactome: R-HSA-2173796Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559585Reactome: R-HSA-69231 |
| Cellular Localisation | CytoplasmAlso Found In The Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 4 Inhibitor B antibodyAnti-Multiple Tumor Suppressor 2 antibodyAnti-Mts-2 antibodyAnti-P14-Ink4b antibodyAnti-P15-Ink4b antibodyAnti-P15ink4b antibodyAnti-CDKN2B antibodyAnti-MTS2 antibody |
Information sourced from Uniprot.org
