![Anti-p120/Catenin antibody [MRQ-5] (STJ16100406)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149123/346744/STJ16100406_1__52049.1681998838.jpg?c=1 "Anti-p120/Catenin antibody [MRQ-5] (STJ16100406)")
![Anti-p120/Catenin antibody [MRQ-5] (STJ16100406)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149123/346744/STJ16100406_1__52049.1681998838.jpg?c=1 "Anti-p120/Catenin antibody [MRQ-5] (STJ16100406)")
Anti-p120/Catenin antibody [MRQ-5] (STJ16100406)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal anti-p120/Catenin for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MRQ-5 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Dilution Range | IHC 1:50 – 1:200 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
Additional Info
| Background | p120 catenin is encoded on chromosome 11q11. Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. A deficiency of E-cadherin results in the intracytoplasmic accumulation of p120 catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 catenin while ductal carcinoma shows reduced membrane p120 catenin without cytoplasmic accumulation. In gastric and colonic carcinoma, strong cytoplasmic p120 catenin is associated with discohesive infiltrative morphology. |
Information sourced from Uniprot.org