| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OTU domain-containing protein 7B is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OTUD7B |
| Gene ID: |
56957 |
| Uniprot ID: |
OTU7B_HUMAN |
| Specificity: |
This antibody detects endogenous levels of OTUD7B at Human |
| Immunogen: |
Synthesized peptide derived from human OTUD7B |
| Post Translational Modifications | Phosphorylated by EGFR. |
| Function | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro).however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin. |
| Protein Name | Otu Domain-Containing Protein 7bCellular Zinc Finger Anti-Nf-Kappa-B ProteinCezanneZinc Finger A20 Domain-Containing Protein 1Zinc Finger Protein Cezanne |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleusShuttles Be Cytoplasm And The Nucleus In A Xpo1/Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 7b antibodyAnti-Cellular Zinc Finger Anti-Nf-Kappa-B Protein antibodyAnti-Cezanne antibodyAnti-Zinc Finger A20 Domain-Containing Protein 1 antibodyAnti-Zinc Finger Protein Cezanne antibodyAnti-OTUD7B antibodyAnti-ZA20D1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
