| Tissue Specificity | Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. |
| Post Translational Modifications | Phosphorylated by EGFR. |
| Function | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro).however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin. Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex. |
| Protein Name | Otu Domain-Containing Protein 7bCellular Zinc Finger Anti-Nf-Kappa-B ProteinCezanneZinc Finger A20 Domain-Containing Protein 1Zinc Finger Protein Cezanne |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleusShuttles Be Cytoplasm And The Nucleus In A Xpo1/Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 7b antibodyAnti-Cellular Zinc Finger Anti-Nf-Kappa-B Protein antibodyAnti-Cezanne antibodyAnti-Zinc Finger A20 Domain-Containing Protein 1 antibodyAnti-Zinc Finger Protein Cezanne antibodyAnti-OTUD7B antibodyAnti-ZA20D1 antibody |
Information sourced from Uniprot.org
