Anti-OTUD3 antibody (STJA0008583)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human OTUD3
General Information
| Short Description | Rabbit polyclonal anti-OTU domain-containing protein 3 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OTUD3 |
| Gene ID | 23252 |
| Uniprot ID | OTUD3_HUMAN |
| Immunogen | Synthesized peptide derived from human OTUD3 |
| Specificity | This antibody detects endogenous levels of OTUD3 at Human |
Additional Info
| Function | Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. |
| Protein Name | Otu Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-5689896Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmNucleusGlucose Or Fatty Acid Promote Nuclear Translocation Upon Acetylation |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 3 antibodyAnti-OTUD3 antibodyAnti-KIAA0459 antibody |
Information sourced from Uniprot.org