Anti-OTOP1 antibody (370-420) (STJ505980)

SKU:
STJ505980-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-OTOP1 (370-420) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: OTOP1
Gene ID: 133060
Uniprot ID: OTOP1_HUMAN
Immunogen Region: 370-420
Immunogen: Synthetic peptide taken within aino acid region 370-420on human Otopetrin-1.
Function Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly-sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates purinergic control of intracellular calcium in vestibular supporting cells. May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol. Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction.
Protein Name Proton Channel Otop1
Otopetrin-1
Hotop1
Database Links Reactome: R-HSA-9729555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Detected In The Gelatinous Membrane Overlying The Inner Ear Macular Epithelium
Alternative Antibody Names Anti-Proton Channel Otop1 antibody
Anti-Otopetrin-1 antibody
Anti-Hotop1 antibody
Anti-OTOP1 antibody

Information sourced from Uniprot.org

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