Anti-OTOF antibody [SRP14417] (STJ11109147)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit polyclonal OTOF antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Clone ID | SRP14417 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:500-1:2000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OTOF |
| Gene ID | 9381 |
| Uniprot ID | OTOF_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Isoform 1 and isoform 3 are found in adult brain. Isoform 2 is expressed in the fetus and in adult brain, heart, placenta, skeletal muscle and kidney. |
| Function | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes. |
| Protein Name | OtoferlinFer-1-Like Protein 2 |
| Database Links | Reactome: R-HSA-9609523Reactome: R-HSA-9662360 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Type Ii Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembraneGolgi Apparatus MembranePresynaptic Cell MembraneCell MembraneDetected At Basolateral Cell Membrane With Synaptic Vesicles Surrounding The Ribbon And At The Presynaptic Plasma Membrane In The Inner Hair Cells (Ihcs) At Postnatal Day 30 (P30)Colocalizes With Gpr25 And Rab8b In Inner Hair Cells |
| Alternative Antibody Names | Anti-Otoferlin antibodyAnti-Fer-1-Like Protein 2 antibodyAnti-OTOF antibodyAnti-FER1L2 antibody |
Information sourced from Uniprot.org