• Immunofluorescence analysis of L-929 cells using Oncostatin M antibody (STJ27935) at dilution of 1:100. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of C6 cells using Oncostatin M antibody (STJ27935) at dilution of 1:100. Blue: DAPI for nuclear staining.
  • Western blot analysis of extracts of various cell lines, using Oncostatin M Antibody (STJ27935) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.

Anti-OSM antibody (26-252) (STJ27935)

SKU:
STJ27935

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-OSM (26-252) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OSM
Gene ID: 5008
Uniprot ID: ONCM_HUMAN
Immunogen Region: 26-252
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-252 of human Oncostatin M (NP_065391.1).
Immunogen Sequence: AAIGSCSKEYRVLLGQLQKQ TDLMQDTSRLLDPYIRIQGL DVPKLREHCRERPGAFPSEE TLRGLGRRGFLQTLNATLGC VLHRLADLEQRLPKAQDLER SGLNIEDLEKLQMARPNILG LRNNIYCMAQLLDNSDTAEP TKAGRGASQPPTPTPASDAF QRKLEGCRFLHGYHRFMHSV GRVFSKWGESPNRSRRHSPH QALRKGVRRTRPSRKGKRLM TRGQLPR
Post Translational Modifications Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
Function Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Protein Name Oncostatin-M
Osm
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-6788467
Cellular Localisation Secreted
Alternative Antibody Names Anti-Oncostatin-M antibody
Anti-Osm antibody
Anti-OSM antibody

Information sourced from Uniprot.org

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