| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Oxysterol-binding protein-related protein 8 (290-340 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OSBPL8 |
| Gene ID: |
114882 |
| Uniprot ID: |
OSBL8_HUMAN |
| Immunogen Region: |
290-340 aa |
| Specificity: |
This antibody detects endogenous levels of OSBL8 at Human |
| Immunogen: |
Synthesized peptide derived from the human OSBL8 at the amino acid range 290-340 |
| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 8Orp-8Osbp-Related Protein 8 |
| Database Links | Reactome: R-HSA-1482801 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneThe Presence Of The N-Terminus Extension Contains An Overall Negative Charge That May Explain The Weak Localization To The Cortical Endoplasmic Reticulum (Probable)Isoform 3: Endoplasmic Reticulum MembraneLocalizes To The Cortical Endoplasmic Reticulum At The Endoplasmic Reticulum-Plasma Membrane Contact Sites |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 8 antibodyAnti-Orp-8 antibodyAnti-Osbp-Related Protein 8 antibodyAnti-OSBPL8 antibodyAnti-KIAA1451 antibodyAnti-ORP8 antibodyAnti-OSBP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
