Anti-Ornithine Carbamoyltransferase/OTC antibody (STJA0038020)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Ornithine Carbamoyltransferase
General Information
| Short Description | Rabbit monoclonal anti-Ornithine Carbamoyltransferase/OTC for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | OTC |
| Gene ID | 5009 |
| Uniprot ID | OTC_HUMAN |
| Immunogen | A synthesized peptide derived from human Ornithine Carbamoyltransferase |
Additional Info
| Tissue Specificity | Mainly expressed in liver and intestinal mucosa. |
| Post Translational Modifications | Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. |
| Function | Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. |
| Protein Name | Ornithine Transcarbamylase - MitochondrialOtcaseOrnithine Carbamoyltransferase - Mitochondrial |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-70635 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Ornithine Transcarbamylase - Mitochondrial antibodyAnti-Otcase antibodyAnti-Ornithine Carbamoyltransferase - Mitochondrial antibodyAnti-OTC antibody |
Information sourced from Uniprot.org