Anti-ORC2 antibody (458-577) (STJ118143)

Name: Anti-ORC2 antibody (458-577) (STJ118143)
SKU: STJ118143
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ118143

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Short Description	Rabbit polyclonal ORC2 (458-577) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	ORC2
Gene ID	4999
Uniprot ID	ORC2_HUMAN
Immunogen Region	458-577
Immunogen Sequence	TSYENSLLVKQSGSLPLSSL THVLRSLTPNARGIFRLLIK YQLDNQDNPSYIGLSFQDFY QQCREAFLVNSDLTLRAQLT EFRDHKLIRTKKGTDGVEYL LIPVDNGTLTDFLEKEEEEA
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 458-577 of human ORC2 (NP_006181.1).

Function	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
Protein Name	Origin Recognition Complex Subunit 2
Database Links	Reactome: R-HSA-113507 Reactome: R-HSA-176187 Reactome: R-HSA-68616 Reactome: R-HSA-68689 Reactome: R-HSA-68867 Reactome: R-HSA-68949 Reactome: R-HSA-68962
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Origin Recognition Complex Subunit 2 antibody Anti-ORC2 antibody Anti-ORC2L antibody

Information sourced from Uniprot.org