Anti-OPTC antibody (20-115) (STJ118941)

Name: Anti-OPTC antibody (20-115) (STJ118941)
SKU: STJ118941
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ118941

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Short Description	Rabbit polyclonal OPTC (20-115) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	OPTC
Gene ID	26254
Uniprot ID	OPT_HUMAN
Immunogen Region	20-115
Immunogen Sequence	ASLPRKERKRREEQMPREGD SFEVLPLRNDVLNPDNYGEV IDLSNYEELTDYGDQLPEVK VTSLAPATSISPAKSTTAPG TPSSNPTMTRPTTAGL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 20-115 of human OPTC (NP_055174.1).

Tissue Specificity	Expressed in cartilage and synovial membranes (at protein level). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level). Expressed in the retinal pigment epithelium (at protein level). Expressed in synovial fibroblasts and subchondral bone osteoblasts.
Post Translational Modifications	O-glycosylated. Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5. Proteolytically cleaved by MMP13. The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology. Sulfated on tyrosine residues.
Function	Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily.
Protein Name	Opticin Oculoglycan
Database Links	Reactome: R-HSA-1474228
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Opticin antibody Anti-Oculoglycan antibody Anti-OPTC antibody Anti-OPT antibody

Information sourced from Uniprot.org