Anti-OPRL1 antibody (STJ192689)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Nociceptin receptor for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OPRL1 |
| Gene ID | 4987 |
| Uniprot ID | OPRX_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | OPRX Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-363 requires GRK3. |
| Function | G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. |
| Protein Name | Nociceptin ReceptorKappa-Type 3 Opioid ReceptorKor-3Orphanin Fq Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleLigand Binding Leads To Receptor Internalization Into Cytoplasmic VesiclesDecreasing The Amount Of Available Receptor At The Cell SurfaceInternalization Requires Phosphorylation At Ser-363Can Recycle To The Cell Membrane |
| Alternative Antibody Names | Anti-Nociceptin Receptor antibodyAnti-Kappa-Type 3 Opioid Receptor antibodyAnti-Kor-3 antibodyAnti-Orphanin Fq Receptor antibodyAnti-OPRL1 antibodyAnti-OOR antibodyAnti-ORL1 antibody |
Information sourced from Uniprot.org