![Anti-OPRK1 nanobody [SAA1169] (STJN000215)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200828/413010/STJN000215-SDS-PAGE-1__36142.1749232528.jpg?c=1 "Anti-OPRK1 nanobody [SAA1169] (STJN000215)")
![Anti-OPRK1 nanobody [SAA1169] (STJN000215)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200828/413010/STJN000215-SDS-PAGE-1__36142.1749232528.jpg?c=1 "Anti-OPRK1 nanobody [SAA1169] (STJN000215)")
Anti-OPRK1 nanobody [SAA1169] (STJN000215)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Kappa-Type Opioid Receptor is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1169 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | OPRK1 |
| Gene ID | 4986 |
| Uniprot ID | OPRK_HUMAN |
Additional Info
| Function | G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
| Protein Name | Kappa-Type Opioid ReceptorK-Or-1Kor-1 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-9022699 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Kappa-Type Opioid Receptor nanobodyAnti-K-Or-1 nanobodyAnti-Kor-1 nanobodyAnti-OPRK1 nanobodyAnti-OPRK nanobody |
Information sourced from Uniprot.org