Anti-OPRD1 antibody (C-Term) (STJA0005801)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids from the C-terminus of human Delta Opiod Receptor protein
General Information
| Short Description | Rabbit polyclonal anti-Delta Opiod Receptor (C-Term) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | PBS + 0.02% NaN3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OPRD1 |
| Gene ID | 4985 |
| Uniprot ID | OPRD_HUMAN |
| Immunogen | Synthetic peptide corresponding to amino acids from the C-terminus of human Delta Opiod Receptor protein |
| Immunogen Region | C-Term |
| Specificity | Reacts with human, mouse and rat DOR-1. |
Additional Info
| Post Translational Modifications | N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation.the ubiquitination is diminished by RTP4. |
| Function | G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. |
| Protein Name | Delta-Type Opioid ReceptorD-Or-1Dor-1 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Delta-Type Opioid Receptor antibodyAnti-D-Or-1 antibodyAnti-Dor-1 antibodyAnti-OPRD1 antibodyAnti-OPRD antibody |
Information sourced from Uniprot.org