![Anti-OLR1/LOX1 nanobody [SAA1291] (STJN000250)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200863/413045/STJN000250-SDS-PAGE-1__00502.1749232557.jpg?c=1 "Anti-OLR1/LOX1 nanobody [SAA1291] (STJN000250)")
![Anti-OLR1/LOX1 nanobody [SAA1291] (STJN000250)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200863/413045/STJN000250-SDS-PAGE-1__00502.1749232557.jpg?c=1 "Anti-OLR1/LOX1 nanobody [SAA1291] (STJN000250)")
Anti-OLR1/LOX1 nanobody [SAA1291] (STJN000250)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Oxidized Low-Density Lipoprotein Receptor 1 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1291 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | OLR1 |
| Gene ID | 4973 |
| Uniprot ID | OLR1_HUMAN |
Additional Info
| Post Translational Modifications | The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated. |
| Function | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis. |
| Protein Name | Oxidized Low-Density Lipoprotein Receptor 1Ox-Ldl Receptor 1C-Type Lectin Domain Family 8 Member ALectin-Like Oxidized Ldl Receptor 1Lox-1Lectin-Like Oxldl Receptor 1Hlox-1Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorSingle-Pass Type Ii Membrane ProteinMembrane RaftSecretedA Secreted Form Also ExistsLocalization To Membrane Rafts Requires Palmitoylation |
| Alternative Nanobody Names | Anti-Oxidized Low-Density Lipoprotein Receptor 1 nanobodyAnti-Ox-Ldl Receptor 1 nanobodyAnti-C-Type Lectin Domain Family 8 Member A nanobodyAnti-Lectin-Like Oxidized Ldl Receptor 1 nanobodyAnti-Lox-1 nanobodyAnti-Lectin-Like Oxldl Receptor 1 nanobodyAnti-Hlox-1 nanobodyAnti-Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form nanobodyAnti-OLR1 nanobodyAnti-CLEC8A nanobodyAnti-LOX1 nanobody |
Information sourced from Uniprot.org