Anti-OLR1 antibody (58-273) (STJ24865)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OLR1 (58-273) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OLR1 |
| Gene ID | 4973 |
| Uniprot ID | OLR1_HUMAN |
| Immunogen Region | 58-273 |
| Immunogen Sequence | MQLSQVSDLLTQEQANLTHQ KKKLEGQISARQQAEEASQE SENELKEMIETLARKLNEKS KEQMELHHQNLNLQETLKRV ANCSAPCPQDWIWHGENCYL FSSGSFNWEKSQEKCLSLDA KLLKINSTADLDFIQQAISY SSFPFWMGLSRRNPSYPWLW EDGSPLMPHLFRVRGAVSQT YPSGTCAYIQRGAVYAENCI LAAFSICQKKANLRAQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 58-273 of human OLR1 (NP_002534.1). |
Additional Info
| Tissue Specificity | Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. |
| Post Translational Modifications | The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated. |
| Function | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis. |
| Protein Name | Oxidized Low-Density Lipoprotein Receptor 1Ox-Ldl Receptor 1C-Type Lectin Domain Family 8 Member ALectin-Like Oxidized Ldl Receptor 1Lox-1Lectin-Like Oxldl Receptor 1Hlox-1Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorSingle-Pass Type Ii Membrane ProteinMembrane RaftSecretedA Secreted Form Also ExistsLocalization To Membrane Rafts Requires Palmitoylation |
| Alternative Antibody Names | Anti-Oxidized Low-Density Lipoprotein Receptor 1 antibodyAnti-Ox-Ldl Receptor 1 antibodyAnti-C-Type Lectin Domain Family 8 Member A antibodyAnti-Lectin-Like Oxidized Ldl Receptor 1 antibodyAnti-Lox-1 antibodyAnti-Lectin-Like Oxldl Receptor 1 antibodyAnti-Hlox-1 antibodyAnti-Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form antibodyAnti-OLR1 antibodyAnti-CLEC8A antibodyAnti-LOX1 antibody |
Information sourced from Uniprot.org