• Western blot analysis of lysates from mouse lung, using OLR1 Rabbit polyclonal antibody (STJ113959) at 1:1000 dilution. _Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. _Lysates/proteins: 25 Mu g per lane. _Blocking buffer: 3% nonfat dry milk in TBST. _Detection: ECL Enhanced Kit. _Exposure time: 90s.

Anti-OLR1 antibody (1-100) (STJ113959)

SKU:
STJ113959

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-OLR1 (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OLR1
Gene ID: 4973
Uniprot ID: OLR1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human OLR1 (NP_002534.1).
Immunogen Sequence: MTFDDLKIQTVKDQPDEKSN GKKAKGLQFLYSPWWCLAAA TLGVLCLGLVVTIMVLGMQL SQVSDLLTQEQANLTHQKKK LEGQISARQQAEEASQESEN
Tissue Specificity Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
Post Translational Modifications The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated.
Function Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis.
Protein Name Oxidized Low-Density Lipoprotein Receptor 1
Ox-Ldl Receptor 1
C-Type Lectin Domain Family 8 Member A
Lectin-Like Oxidized Ldl Receptor 1
Lox-1
Lectin-Like Oxldl Receptor 1
Hlox-1
Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Single-Pass Type Ii Membrane Protein
Membrane Raft
Secreted
A Secreted Form Also Exists
Localization To Membrane Rafts Requires Palmitoylation
Alternative Antibody Names Anti-Oxidized Low-Density Lipoprotein Receptor 1 antibody
Anti-Ox-Ldl Receptor 1 antibody
Anti-C-Type Lectin Domain Family 8 Member A antibody
Anti-Lectin-Like Oxidized Ldl Receptor 1 antibody
Anti-Lox-1 antibody
Anti-Lectin-Like Oxldl Receptor 1 antibody
Anti-Hlox-1 antibody
Anti-Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form antibody
Anti-OLR1 antibody
Anti-CLEC8A antibody
Anti-LOX1 antibody

Information sourced from Uniprot.org

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