Anti-Olig2 antibody (N-Term) (STJA0040626)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenN-terminal half of human OLIG2 was used to immunize chickens to avoid cross-reactivity with OLIG3.
General Information
| Short Description | Chicken polyclonal anti-Olig2 (N-Term) for use in IHC, ICC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ICC/WB |
| Host | Chicken |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Concentration | 0.2 mg/mL |
| Purification | Affinity-Purified IgY |
| Dilution Range | WB 1:1000IHC 1:1000ICC 1:1000 |
| Formulation | Phosphate-buffered saline (10 mM) isotonic (0.9%, w/v) saline (“PBS, pH 7.2) with sodium azide (0.02%, w/v) added as a preservative." |
| Storage Instruction | Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody. |
Target Information
| Gene Symbol | OLIG2 |
| Gene ID | 10215 |
| Uniprot ID | OLIG2_HUMAN |
| Immunogen | N-terminal half of human OLIG2 was used to immunize chickens to avoid cross-reactivity with OLIG3. |
| Immunogen Region | N-Term |
| Immunogen Sequence | Human |
Additional Info
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Protein Name | Oligodendrocyte Transcription Factor 2Oligo2Class B Basic Helix-Loop-Helix Protein 1Bhlhb1Class E Basic Helix-Loop-Helix Protein 19Bhlhe19Protein Kinase C-Binding Protein 2Protein Kinase C-Binding Protein Rack17 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmThe Nls Contained In The Bhlh Domain Could Be Masked In The Native Form And Translocation To The Nucleus Could Be Mediated By Interaction Either With Class E Bhlh Partner Protein Or With Nkx2-2 |
| Alternative Antibody Names | Anti-Oligodendrocyte Transcription Factor 2 antibodyAnti-Oligo2 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 1 antibodyAnti-Bhlhb1 antibodyAnti-Class E Basic Helix-Loop-Helix Protein 19 antibodyAnti-Bhlhe19 antibodyAnti-Protein Kinase C-Binding Protein 2 antibodyAnti-Protein Kinase C-Binding Protein Rack17 antibodyAnti-OLIG2 antibodyAnti-BHLHB1 antibodyAnti-BHLHE19 antibodyAnti-PRKCBP2 antibodyAnti-RACK17 antibody |
Information sourced from Uniprot.org