| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-OIP106/TRAK1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.3-1.5µg/mlELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
TRAK1 |
| Gene ID: |
22906 |
| Uniprot ID: |
TRAK1_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_001036111.1 |
| Specificity: |
This antibody is only expected to recognise isoform 1 (NP_001036111.1) only. |
| Immunogen Sequence: |
CGAKLSKQTSLR |
| Post Translational Modifications | O-glycosylated. Glycosylated by OGT.glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT. |
| Function | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. |
| Protein Name | Trafficking Kinesin-Binding Protein 1106 Kda O-Glcnac Transferase-Interacting ProteinProtein Milton |
| Database Links | Reactome: R-HSA-6802952Reactome: R-HSA-9013419Reactome: R-HSA-9013425 |
| Cellular Localisation | CytoplasmNucleusMitochondrionEarly EndosomeEndosomeMitochondrion MembraneCell CortexPredominantly Associated With Early EndosomeThe Localization To Early Endosomes Depends On Its Interaction With Hgs/HrsColocalizes With Mgarp At The Mitochondria |
| Alternative Antibody Names | Anti-Trafficking Kinesin-Binding Protein 1 antibodyAnti-106 Kda O-Glcnac Transferase-Interacting Protein antibodyAnti-Protein Milton antibodyAnti-TRAK1 antibodyAnti-KIAA1042 antibodyAnti-OIP106 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
