Anti-OGG1 antibody (1-345) (STJ24860)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OGG1 (1-345) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OGG1 |
| Gene ID | 4968 |
| Uniprot ID | OGG1_HUMAN |
| Immunogen Region | 1-345 |
| Immunogen Sequence | MPARALLPRRMGHRTLASTP ALWASIPCPRSELRLDLVLP SGQSFRWREQSPAHWSGVLA DQVWTLTQTEEQLHCTVYRG DKSQASRPTPDELEAVRKYF QLDVTLAQLYHHWGSVDSHF QEVAQKFQGVRLLRQDPIEC LFSFICSSNNNIARITGMVE RLCQAFGPRLIQLDDVTYHG FPSLQALAGPEVEAHLRKLG LGYRARYVSASARAILEEQG GLAWLQQLRESSYEEAHKA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human OGG1 (NP_002533.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
| Protein Name | N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site LyaseAp Lyase |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-110357Reactome: R-HSA-5649702Reactome: R-HSA-9656255Reactome: R-HSA-9656256Reactome: R-HSA-9657050 O15527-4 |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleNucleus MatrixTogether With Apex1 Is Recruited To Nuclear Speckles In Uva-Irradiated CellsIsoform 1a: NucleusIsoform 2a: Mitochondrion |
| Alternative Antibody Names | Anti-N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase antibodyAnti-Ap Lyase antibodyAnti-OGG1 antibodyAnti-MMH antibodyAnti-MUTM antibodyAnti-OGH1 antibody |
Information sourced from Uniprot.org