Anti-OFD1 antibody (STJA0007287)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human OFD1
General Information
| Short Description | Rabbit polyclonal anti-Centriole and centriolar satellite protein OFD1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OFD1 |
| Gene ID | 8481 |
| Uniprot ID | OFD1_HUMAN |
| Immunogen | Synthesized peptide derived from human OFD1 |
| Specificity | This antibody detects endogenous levels of OFD1 at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-735, by the cAMP-dependent protein kinase PKA, triggers ubiquitination and proteasomal degradation of OFD1. Also increases its interaction with TBC1D31 and regulates its function in ciliogenesis. Ubiquitinated by PJA2, upon phosphorylation at Ser-735 by PKA, leads to the proteasomal degradation of OFD1. |
| Function | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation. |
| Protein Name | Centriole And Centriolar Satellite Protein Ofd1Oral-Facial-Digital Syndrome 1 ProteinProtein 71-7a |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5610787Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyNucleusCentriolar SatelliteLocalizes To Centriole Distal Ends And To Centriolar SatellitesLocalization To Centrioles And Pericentriolar Satellites May Be Mediated By Kiaa0753/Ofip |
| Alternative Antibody Names | Anti-Centriole And Centriolar Satellite Protein Ofd1 antibodyAnti-Oral-Facial-Digital Syndrome 1 Protein antibodyAnti-Protein 71-7a antibodyAnti-OFD1 antibodyAnti-CXorf5 antibody |
Information sourced from Uniprot.org