Anti-OCLN antibody (350-400 aa) (STJ192969)

Name: Anti-OCLN antibody (350-400 aa) (STJ192969)
SKU: STJ192969
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenSynthesized peptide derived from part of the human protein at the amino acid350-400

STJ192969

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Short Description	Rabbit polyclonal anti-Occludin (350-400 aa) for use in WB, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	1 mg/mL
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range	WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	OCLN
Gene ID	100506658
Uniprot ID	OCLN_HUMAN
Immunogen	Synthesized peptide derived from part of the human protein at the amino acid350-400
Immunogen Region	350-400 aa
Specificity	OCLN Polyclonal Antibody detects endogenous levels of protein.

Post Translational Modifications	Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1. (Microbial infection) Cleaved by S.pyogenes SpeB protease.leading to its degradation. Degradation by SpeB promotes bacterial translocation across the host epithelial barrier.
Function	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes.
Protein Name	Occludin
Database Links	Reactome: R-HSA-351906 Reactome: R-HSA-8935964
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Junction Tight Junction
Alternative Antibody Names	Anti-Occludin antibody Anti-OCLN antibody

Information sourced from Uniprot.org