Anti-OCA2 antibody (1-180) (STJ27620)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OCA2 (1-180) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OCA2 |
| Gene ID | 4948 |
| Uniprot ID | P_HUMAN |
| Immunogen Region | 1-180 |
| Immunogen Sequence | MHLEGRDGRRYPGAPAVELL QTSVPSGLAELVAGKRRLPR GAGGADPSHSCPRGAAGQSS WAPAGQEFASFLTKGRSHSS LPQMSSSRSKDSCFTENTPL LRNSLQEKGSRCIPVYHPEF ITAEESWEDSSADWERRYLL SREVSGLSASASSEKGDLLD SPHIRLRLSKLRRCVQWLKV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human OCA2 (NP_000266.2). |
Additional Info
| Tissue Specificity | Expressed in melanocytes and retinal pigment epithelium. |
| Function | Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. |
| Protein Name | P ProteinMelanocyte-Specific Transporter ProteinPink-Eyed Dilution Protein Homolog |
| Database Links | Reactome: R-HSA-5662702 |
| Cellular Localisation | Melanosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-P Protein antibodyAnti-Melanocyte-Specific Transporter Protein antibodyAnti-Pink-Eyed Dilution Protein Homolog antibodyAnti-OCA2 antibodyAnti-D15S12 antibodyAnti-P antibody |
Information sourced from Uniprot.org