• Western blot analysis of extracts of various cell lines, using OCA2 antibody (STJ27620) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Anti-OCA2 antibody (1-180) (STJ27620)

SKU:
STJ27620

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-OCA2 (1-180) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OCA2
Gene ID: 4948
Uniprot ID: P_HUMAN
Immunogen Region: 1-180
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human OCA2 (NP_000266.2).
Immunogen Sequence: MHLEGRDGRRYPGAPAVELL QTSVPSGLAELVAGKRRLPR GAGGADPSHSCPRGAAGQSS WAPAGQEFASFLTKGRSHSS LPQMSSSRSKDSCFTENTPL LRNSLQEKGSRCIPVYHPEF ITAEESWEDSSADWERRYLL SREVSGLSASASSEKGDLLD SPHIRLRLSKLRRCVQWLKV
Tissue Specificity Expressed in melanocytes and retinal pigment epithelium.
Function Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis.
Protein Name P Protein
Melanocyte-Specific Transporter Protein
Pink-Eyed Dilution Protein Homolog
Database Links Reactome: R-HSA-5662702
Cellular Localisation Melanosome Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-P Protein antibody
Anti-Melanocyte-Specific Transporter Protein antibody
Anti-Pink-Eyed Dilution Protein Homolog antibody
Anti-OCA2 antibody
Anti-D15S12 antibody
Anti-P antibody

Information sourced from Uniprot.org

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