| Short Description : | Rabbit polyclonal OAZ1 (1-68) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OAZ1 |
| Gene ID: | 4946 |
| Uniprot ID: | OAZ1_HUMAN |
| Immunogen Region: | 1-68 |
| Immunogen Sequence: | MVKSSLQRILNSHCFAREKE GDKPSATIHASRTMPLLSLH SRGGSSSESSRVSLHCCSNP GPGPRWCS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human OAZ1 (NP_004143.1). |
| Function | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. |
| Protein Name | Ornithine Decarboxylase Antizyme 1Az1Odc-Az |
| Database Links | Reactome: R-HSA-350562 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ornithine Decarboxylase Antizyme 1 antibodyAnti-Az1 antibodyAnti-Odc-Az antibodyAnti-OAZ1 antibodyAnti-OAZ antibody |
Information sourced from Uniprot.org
