Anti-OAS3 antibody (STJA0006993)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human OAS3
General Information
| Short Description | Rabbit polyclonal anti-2 5 oligoadenylate synthase 3oligoA synthase 3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OAS3 |
| Gene ID | 4940 |
| Uniprot ID | OAS3_HUMAN |
| Immunogen | Synthesized peptide derived from human OAS3 |
| Specificity | This antibody detects endogenous levels of OAS3 at Human, Mouse, Rat |
Additional Info
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). |
| Protein Name | 2'-5'-Oligoadenylate Synthase 3(2-5'Oligo(A Synthase 32-5a Synthase 3P100 OasP100oas |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-2'-5'-Oligoadenylate Synthase 3 antibodyAnti-(2-5'Oligo(A Synthase 3 antibodyAnti-2-5a Synthase 3 antibodyAnti-P100 Oas antibodyAnti-P100oas antibodyAnti-OAS3 antibodyAnti-P antibodyAnti-OKcl.4 antibody |
Information sourced from Uniprot.org