Anti-OA1 antibody (STJ13100148)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from rat OA1 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-OA1 for use in IHC and WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1 :1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Gpr143 |
| Gene ID | 18241 |
| Uniprot ID | GP143_MOUSE |
| Immunogen | A synthetic peptide from rat OA1 conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for OA1. |
Additional Info
| Function | Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane.this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. |
| Protein Name | G-Protein Coupled Receptor 143Moa1Ocular Albinism Type 1 Protein Homolog |
| Database Links | Reactome: R-MMU-375280Reactome: -MMU-416476 |
| Cellular Localisation | Melanosome MembraneMulti-Pass Membrane ProteinLysosome MembraneApical Cell MembraneDistributed Throughout The Endo-Melanosomal System But Most Of Endogenous Protein Is Localized In Unpigmented Stage Ii MelanosomesIts Expression On The Apical Cell Membrane Is Sensitive To Tyrosine |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 143 antibodyAnti-Moa1 antibodyAnti-Ocular Albinism Type 1 Protein Homolog antibodyAnti-Gpr143 antibodyAnti-Oa1 antibody |
Information sourced from Uniprot.org